Click Here to return To Results

 

Serum Iron and Neuroleptic Malignant Syndrome Lancet 338:149-151, Rosebush,P.I.&Mazurek,M.F., 1991 See this aricle in Pubmed Article Abstract Neuroleptic malignant syndrome(NMS)is a fulminant,life-threatening reaction to neuroleptic medications.The only consistently described biochemical abnormalities are increased creatine kinase and leucocytosis. Because of a possible association between NMS and dopaminergic function and between serum iron and dopaminergic function,we prospectively measured serum iron in 26 episodes of NMS in twenty-three patients.In 25 episodes (96%)serum iron concentration was 10 umol/lower-more than 2 SD below the mean normal value.Serum iron in 11 episodes(36%)was 4 umol/l or lower.In each episode for which data are available,serum iron returned to normal upon resolution of the NMS.Serum iron may be a helpful adjunct for the diagnosis of the disorder.The pronounced reduction in serum iron suggests that the acute phase reaction may have a role in NMS.

Related Tags

(click to filter results - removes previous filter) iron,serum neuroleptic malignant syndrome

Click Here to return To Results